The basis of regenerative medicine is restoring the tissue’s original function. Modern regenerative therapy makes use of natural biological polymers that release growth factors that are understood and recognized by the immune system. Collagen is the most widely used biological polymer because it is a part of the extracellular matrix in most living tissues. The versatility of collagen makes it a wise choice for use in joints, bones, connective tissues and skin. It does this by forming a network of fibers that repairs damaged tissue and facilitates cellular interactions.
Collagen NetworksCollagen forms a type of network or scaffold. This substrate influences the behavior of nearby cells, signaling to them to become more active. Proteins, ligands and other growth factors congregate at the collagen scaffold. This process allows collagen to engineer a specific scaffold for different types of tissues.
There are different types of collagen networks, with some being more common in skin and others more common in cartilage. Each collagen scaffold is unique and has the ability to generate the right type of new tissue based on its location in the body and its specific composition.